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Several reports have shown a higher GSSG/GSH ratio in different fluids (27, 28), also in saliva of patients compared with healthy subjects (29-31)

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Allosteric regulation has long been recognized for other NRs [77, 81] and has become more apparent and accepted as a mode of regulation for AR activity over the past decade, based on literature reports as those described above

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Patients in both groups were evaluated at baseline and after 2 months (of receiving the NAC or waitlist control period) with an integrated Position Emission Tomography (PET)/ Magnetic Resonance Imaging (MRI) scanner, using 18F Fluorodeoxyglucose (FDG) to measure cerebral glucose metabolism